Cb1 Receptors in the Thalamic Reticular Nucleus during Acute Immobilization Stress of the Rat: an Immunohistochemical Study
نویسندگان
چکیده
INTRODUCTION The endocannabinoid system is composed of endogenous ligands, their enzymes for biosynthesis and degradation and cannabinoid receptors (13). The CB1 receptor is one of the most abundant G protein-coupled receptors expressed in the central nervous system (5). The regional distribution of CB1 receptors has been described in the rat brain (10, 15). During aging the number of CB1 receptors in the
منابع مشابه
Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats
The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...
متن کاملMorphology and Synaptic Organization of Non-Dopaminergic Nigral Projections to the Medio Dorsal Thalamic Nucleus of the Rat, a Study by Anterograde Transport of PHA-L
Background: Mediodorsal (MD) thalamic nucleus, which is considered to take place between extra pyramidal and limbic feedback circuit, receives projective fibers from ventrolateral neurons of reticular part of substantia nigra (SNr). In order to better understand the influence and chemical reaction of these fibers upon MD nucleus, the morphology and synaptology of them were examined in the prese...
متن کاملCB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin
Objective(s): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting results and the mechanism(s) by which antipsychotics affect brain neurotensin neurotransmission have no...
متن کاملCapsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis
Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...
متن کاملAssessing the effect of intra-paragigantocellularis lateralis injection of 17β- estradiol on the acute and persistent pain in the male rat
Introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. Beside its autonomic functions, paragigantocellularis lateralis (LPGi) nucleus is also involved in pain modulation. The aim of the current study was to investigate the role of the intracellular estrogen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015